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The reactions have been Zofran brand Order for inclusion due to a combination of their seriousness, frequency of reporting, or potential causal Zofran brand Order to ondansetron. Rare cases of hypersensitivity reactions, sometimes severe e. A positive lymphocyte transformation test to ondansetron has been reported, which suggests immunologic sensitivity to ondansetron. Hepatobiliary Liver enzyme abnormalities have been reported. Liver failure and death have been reported in patients with cancer receiving concurrent medications including potentially hepatotoxic cytotoxic chemotherapy and antibiotics.

Local Reactions Pain, redness, and burning at site of injection. Neurological Oculogyric crisis, appearing alone, as Zofran brand Order as with other dystonic reactions. Transient dizziness during or shortly after intravenous infusion. Skin Urticaria, Stevens-Johnson syndrome, and toxic generic Strattera necrolysis. These cases of transient blindness Zofran brand Order reported to resolve within a few minutes up to 48 hours. Transient blurred vision, in some cases associated with abnormalities of accommodation, have also been reported. Chemotherapy In humans, carmustine, etoposide, and cisplatin do not Zofran brand Order the pharmacokinetics of ondansetron. In a crossover trial in 76 pediatric patients, intravenous ondansetron did not increase blood levels of high-dose methotrexate.

Alfentanil And Atracurium Ondansetron does not alter the respiratory depressant effects produced by alfentanil or the degree of neuromuscular blockade produced by atracurium.

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Interactions with general or local anesthetics have not been studied. In addition, postmarketing cases of Torsade de Pointes have been reported in patients using ondansetron. ECG monitoring is recommended in patients with electrolyte abnormalities e. Serotonin Syndrome The Zofran brand Order of Zofran brand Order syndrome has been reported with 5-HT3 receptor antagonists. Some of the reported cases were fatal. The majority of reports of serotonin syndrome related to 5-HT3 receptor antagonist use occurred in a post-anesthesia care unit or an infusion center. Symptoms associated with serotonin syndrome may include the following combination of signs and symptoms: It should not be used instead of nasogastric suction.

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Ondansetron was not mutagenic in Zofran brand Order tests for mutagenicity. There are, however, no adequate and well-controlled studies in pregnant women. Nursing Mothers Ondansetron buy Sildenafil Citrate excreted in the breast milk of rats, Zofran Brand Order. It is not known whether ondansetron is excreted in Zofran brand Order milk.

Pediatric Use Little information is available about the use of ondansetron in pediatric surgical patients younger than 1 month. Patients should be managed with appropriate supportive therapy. These doses are more than 10 times the recommended daily dose. In addition to the adverse reactions listed above, the Zofran brand Order events have been described in the setting of ondansetron overdose: Hypotension and faintness occurred in another patient that took 48 mg of ondansetron hydrochloride tablets. Following infusion of 32 mg over only a 4-minute period, a vasovagal episode with transient second-degree heart block was observed. In all instances, the events resolved completely. Reported symptoms included somnolence, agitation, tachycardia, tachypnea, hypertension, flushing, mydriasis, diaphoresis, myoclonic movements, horizontal nystagmus, hyperreflexia, and seizure.

Patients required supportive care, including intubation in some cases, with complete recovery without sequelae within 1 to 2 days. Anaphylactic reactions have been reported in patients taking ondansetron. Pharmacodynamics QTc interval prolongation was studied in a double-blind, single intravenous dose, placebo- and positive-controlled, crossover trial in 58 healthy subjects.

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Pharmacodynamics QTc Zofran brand Order prolongation was studied in a double-blind, the following events have been described in the Zofran brand Order of ondansetron overdose: Ondansetron was not mutagenic in standard tests for mutagenicity, the following events have been described in the Zofran brand Order of ondansetron overdose: Ondansetron was not mutagenic in standard tests for mutagenicity, the following events have been described in the setting of ondansetron overdose: Ondansetron was not mutagenic in standard tests for mutagenicity. It should not be used instead of nasogastric suction.

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